Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Roivant Sciences Ltd. 75,000,000 61.43 -- 6/30/18
Renaissance Technologies LLC 1,303,600 1.07 -630,200 6/30/18
BlackRock Institutional Trust Company, N.A. 1,252,858 1.03 -1,494,922 6/30/18
IPL Advisers, LLC 1,207,958 0.99 -- 12/31/17
PRIMECAP Management Company 1,082,900 0.89 -101,400 6/30/18
Adage Capital Management, L.P. 1,000,000 0.82 1,000,000 6/30/18
Millennium Management LLC 961,987 0.79 -368,923 6/30/18
Hudson Bay Capital Management LP 771,900 0.63 196,900 6/30/18
Connor, Clark & Lunn Investment Management Ltd. 495,450 0.41 320,450 6/30/18
Marshall Wace LLP 464,653 0.38 464,653 6/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
iShares NASDAQ Biotechnology ETF 1,256,728 1.03 3,870 8/31/18
PRIMECAP Odyssey Aggressive Growth Fund 825,000 0.68 -- 6/30/18
UBS (Lux) Equity Fund - Biotech 283,360 0.23 40,197 12/31/17
Vanguard US Opportunities Fund 193,900 0.16 -101,400 6/30/18
Virtus LifeSci Biotech Clinical Trials ETF 143,477 0.12 -71,430 7/31/18
ONELIFE FUND 80,000 0.07 80,000 12/31/17
Vanguard Health Care Index Fund 73,328 0.06 3,808 8/31/18
Fidelity Small Cap Index Fund 65,726 0.05 1,706 4/30/18
CREF Stock Account 59,855 0.05 -101,840 3/31/18
DekaLux-BioTech 49,000 0.04 -1,000 6/30/18

* Insider values reflect direct beneficial ownership.