Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Roivant Sciences Ltd. 75,000,000 69.75 -- 9/6/17
Fidelity Management & Research Company 7,235,632 6.73 6,558,462 6/30/17
Capital Research Global Investors 3,453,800 3.21 619,226 6/30/17
PRIMECAP Management Company 3,337,202 3.10 458,272 6/30/17
T. Rowe Price Associates, Inc. 2,879,898 2.68 679,226 6/30/17
Janus Henderson Investors 2,063,549 1.92 -2,435,442 6/30/17
D. E. Shaw & Co., L.P. 1,687,335 1.57 155,275 6/30/17
Franklin Advisers, Inc. 1,463,582 1.36 -149,100 6/30/17
BlackRock Institutional Trust Company, N.A. 1,166,616 1.08 207,315 6/30/17
Camber Capital Management LLC 1,000,000 0.93 1,000,000 6/30/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Fidelity Contrafund 3,820,708 3.55 -47,600 7/31/17
PRIMECAP Odyssey Aggressive Growth Fund 2,965,000 2.76 461,000 6/30/17
American Funds SMALLCAP World Fund 2,076,800 1.93 -- 6/30/17
T. Rowe Price Health Sciences Fund 1,695,482 1.58 -20,271 6/30/17
Fidelity Select Biotechnology Portfolio 1,101,769 1.02 -81,300 7/31/17
Franklin Templeton Invest-Biotechnology Discovery 928,500 0.86 -- 7/31/17
Janus Henderson Global Life Sciences Fund 750,987 0.70 -40,834 3/31/17
Janus Henderson Triton Fund 739,251 0.69 -181,893 6/30/17
Fidelity Advisor New Insights Fund 714,590 0.66 -- 7/31/17
American Funds Insurance Series Global Small Capitalization Fund 705,000 0.66 -52,774 6/30/17

* Insider values reflect direct beneficial ownership.