Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Roivant Sciences Ltd. 75,000,000 61.33 -- 6/30/18
Renaissance Technologies LLC 2,091,700 1.71 788,100 9/30/18
BlackRock Institutional Trust Company, N.A. 1,422,048 1.16 169,190 9/30/18
IPL Advisers, LLC 1,207,958 0.99 -- 12/31/17
PRIMECAP Management Company 1,082,900 0.89 -- 9/30/18
Hudson Bay Capital Management LP 1,010,000 0.83 238,100 9/30/18
Adage Capital Management, L.P. 1,000,000 0.82 -- 9/30/18
Connor, Clark & Lunn Investment Management Ltd. 559,602 0.46 64,152 9/30/18
Millennium Management LLC 496,245 0.41 -465,742 9/30/18
UBS Asset Management (Switzerland) 296,560 0.24 40,197 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
iShares NASDAQ Biotechnology ETF 1,413,048 1.16 -9,000 10/31/18
PRIMECAP Odyssey Aggressive Growth Fund 825,000 0.67 -- 9/30/18
UBS (Lux) Equity Fund - Biotech 283,360 0.23 40,197 12/31/17
Vanguard US Opportunities Fund 193,900 0.16 -- 9/30/18
Virtus LifeSci Biotech Clinical Trials ETF 124,456 0.10 -90,451 9/30/18
ONELIFE FUND 80,000 0.07 80,000 12/31/17
Vanguard Health Care Index Fund 76,116 0.06 1,156 10/31/18
DekaLux-BioTech 49,000 0.04 -1,000 6/30/18
ProShares Ultra Nasdaq Biotechnology 48,461 0.04 1,934 10/31/18
Fidelity NASDAQ Composite Index Tracking Stock 38,149 0.03 1,298 9/30/18

* Insider values reflect direct beneficial ownership.