Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Roivant Sciences Ltd. 75,000,000 69.58 -- 9/6/17
BlackRock Institutional Trust Company, N.A. 2,747,780 2.55 -17,717 3/31/18
Renaissance Technologies LLC 1,933,800 1.79 1,721,400 3/31/18
Millennium Management LLC 1,330,910 1.23 847,946 3/31/18
IPL Advisers, LLC 1,207,958 1.12 -- 12/31/17
PRIMECAP Management Company 1,184,300 1.10 -1,383,000 3/31/18
Deutsche Asset Management Americas 1,096,611 1.02 547,889 3/31/18
Two Sigma Investments, LP 618,158 0.57 461,156 3/31/18
Hudson Bay Capital Management LP 575,000 0.53 225,000 3/31/18
State Street Global Advisors (US) 557,903 0.52 -12,140 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
iShares NASDAQ Biotechnology ETF 1,320,324 1.22 -42,665 4/30/18
PRIMECAP Odyssey Aggressive Growth Fund 825,000 0.77 -1,383,000 3/31/18
iShares Russell 2000 ETF 640,255 0.59 -2,808 4/30/18
Vanguard US Opportunities Fund 295,300 0.27 -11,402 3/31/18
UBS (Lux) Equity Fund - Biotech 283,360 0.26 40,197 12/31/17
iShares Russell 2000 Growth ETF 272,084 0.25 6,050 4/30/18
Virtus LifeSci Biotech Clinical Trials ETF 138,368 0.13 123,556 3/31/18
Hartford SmallCap Growth Fund 78,579 0.07 -- 3/31/18
Hartford SmallCap Growth HLS Fund 76,658 0.07 -- 3/31/18
Vanguard Health Care Index Fund 69,384 0.06 -272 4/30/18

* Insider values reflect direct beneficial ownership.