Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Roivant Sciences Ltd. 75,000,000 69.58 -- 9/6/17
Great Point Partners, LLC 2,850,000 2.64 2,840,321 12/31/17
BlackRock Institutional Trust Company, N.A. 2,765,497 2.57 1,458,854 12/31/17
PRIMECAP Management Company 2,567,300 2.38 -843,500 12/31/17
T. Rowe Price Associates, Inc. 2,436,618 2.26 465,180 12/31/17
IPL Advisers, LLC 1,207,958 1.12 -- 12/31/17
OxFORD Asset Management 1,127,016 1.05 257,182 12/31/17
Fidelity Management & Research Company 1,070,715 0.99 -2,156,342 12/31/17
Ice Pond Lane Advisers, LLC 1,030,324 0.96 -- 12/31/17
Franklin Advisers, Inc. 1,025,434 0.95 -338,200 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
PRIMECAP Odyssey Aggressive Growth Fund 2,208,000 2.05 -841,806 12/31/17
iShares NASDAQ Biotechnology ETF 1,362,989 1.26 -87,555 3/31/18
iShares Russell 2000 ETF 643,063 0.60 -5,733 3/31/18
Franklin Biotechnology Discovery Fund 383,734 0.36 -126,100 12/31/17
T. Rowe Price Small Cap Stock Fund 362,460 0.34 -2,200 12/31/17
T. Rowe Price New Horizons Fund 337,757 0.31 202,580 12/31/17
Vanguard US Opportunities Fund 306,702 0.28 306,702 6/30/17
UBS (Lux) Equity Fund - Biotech 283,360 0.26 40,197 12/31/17
iShares Russell 2000 Growth ETF 266,034 0.25 -3,575 3/31/18
CREF Stock Account 161,695 0.15 -- 2/28/18

* Insider values reflect direct beneficial ownership.